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Título : | Fingerprint Analysis and Identification of Strains ST309 as a Potential High Risk Clone in a Pseudomonas aeruginosa Population Isolated from Children with Bacteremia in Mexico City. |
Autor(es) : | Morales Espinosa, Maria del Rosario Delgado Sapien, Gabriela Espinosa Camacho, Luis Fernando Isselo, Dassaev Alanis Mendez, Jose Luis Rodriguez, Cristina Miranda Novales, Maria Guadalupe Cravioto Quintana, Alejandro Rafael |
En : | Frontiers in Microbiology (1664-302X) vol. 8, 1-8 (2017) |
Número completo : | https://www.ncbi.nlm.nih.gov/pmc/issues/284457/ |
Abstract : | Pseudomonas aeruginosa is an opportunistic pathogen and is associated with nosocomial infections. Its ability to thrive in a broad range of environments is due to a large and diverse genome of which its accessory genome is part. The objective of this study was to characterize P. aeruginosa strains isolated from children who developed bacteremia, using pulse-field gel electrophoresis, and in terms of its genomic islands, virulence genes, multilocus sequence type, and antimicrobial susceptibility. Our results showed that P. aeruginosa strains presented the seven virulence genes: toxA, lasB, lecA, algR, plcH, phzA1, and toxR, a type IV pilin alleles (TFP) group I or II. Additionally, we detected a novel pilin and accessory gene, expanding the number of TFP alleles to group VI. All strains presented the PAPI-2 Island and the majority were exoU+ and exoS+ genotype. Ten percent of the strains were multi-drug resistance phenotype, 18% extensively drug-resistance, 68% moderately resistance and only 3% were susceptible to all the antimicrobial tested. The most prevalent acquired ?-Lactamase was KPC. We identified a group of ST309 strains, as a potential high risk clone. Our finding also showed that the strains isolated from patients with bacteremia have important virulence factors involved in colonization and dissemination as: a TFP group I or II; the presence of the exoU gene within the PAPI-2 island and the presence of the exoS gene. |
Palabras clave : | Bacteriología Pseudomona aeruginosa Genes exoS y exoU Genómica Alelos de TFP ST309 Bacteremia |
Fecha de publicación : | 2017 |
DOI : | 10.3389/fmicb.2017.00313 |
URI : | http://ru.facmed.unam.mx/jspui/handle/FACMED_UNAM/A58 |
Aparece en las colecciones: | Artículos |
Texto completo:
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FACMED_UNAMA58.pdf | 2.79 MB | Adobe PDF | Visualizar/Abrir |
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