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http://ru.facmed.unam.mx/jspui/handle/FACMED_UNAM/A58
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Morales Espinosa, Maria del Rosario | |
dc.contributor.author | Delgado Sapien, Gabriela | |
dc.contributor.author | Espinosa Camacho, Luis Fernando | |
dc.contributor.author | Isselo, Dassaev | |
dc.contributor.author | Alanis Mendez, Jose Luis | |
dc.contributor.author | Rodriguez, Cristina | |
dc.contributor.author | Miranda Novales, Maria Guadalupe | |
dc.contributor.author | Cravioto Quintana, Alejandro Rafael | |
dc.coverage.spatial | CH | |
dc.date.accessioned | 2019-06-17T17:23:28Z | - |
dc.date.available | 2019-06-17T17:23:28Z | - |
dc.date.issued | 2017 | |
dc.identifier.uri | http://ru.facmed.unam.mx/jspui/handle/FACMED_UNAM/A58 | - |
dc.description.abstract | Pseudomonas aeruginosa is an opportunistic pathogen and is associated with nosocomial infections. Its ability to thrive in a broad range of environments is due to a large and diverse genome of which its accessory genome is part. The objective of this study was to characterize P. aeruginosa strains isolated from children who developed bacteremia, using pulse-field gel electrophoresis, and in terms of its genomic islands, virulence genes, multilocus sequence type, and antimicrobial susceptibility. Our results showed that P. aeruginosa strains presented the seven virulence genes: toxA, lasB, lecA, algR, plcH, phzA1, and toxR, a type IV pilin alleles (TFP) group I or II. Additionally, we detected a novel pilin and accessory gene, expanding the number of TFP alleles to group VI. All strains presented the PAPI-2 Island and the majority were exoU+ and exoS+ genotype. Ten percent of the strains were multi-drug resistance phenotype, 18% extensively drug-resistance, 68% moderately resistance and only 3% were susceptible to all the antimicrobial tested. The most prevalent acquired ?-Lactamase was KPC. We identified a group of ST309 strains, as a potential high risk clone. Our finding also showed that the strains isolated from patients with bacteremia have important virulence factors involved in colonization and dissemination as: a TFP group I or II; the presence of the exoU gene within the PAPI-2 island and the presence of the exoS gene. | |
dc.language.iso | en | |
dc.publisher | Frontiers Media S.A. | |
dc.rights | openAccess | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.subject | Bacteriología | |
dc.subject | Pseudomona aeruginosa | |
dc.subject | Genes exoS y exoU | |
dc.subject | Genómica | |
dc.subject | Alelos de TFP | |
dc.subject | ST309 | |
dc.subject | Bacteremia | |
dc.subject.classification | Medicina y Ciencias de la Salud | |
dc.subject.other | Bacteriology | |
dc.subject.other | Pseudomonas aeruginosa | |
dc.subject.other | exoS and exoU genes | |
dc.subject.other | Genomics | |
dc.subject.other | TFP alleles | |
dc.subject.other | ST309 | |
dc.subject.other | Bacteremia | |
dc.title | Fingerprint Analysis and Identification of Strains ST309 as a Potential High Risk Clone in a Pseudomonas aeruginosa Population Isolated from Children with Bacteremia in Mexico City. | |
dc.type | Artículo | |
dc.type | publishedVersion | |
dcterms.bibliographicCitation | Frontiers in Microbiology (1664-302X) vol. 8, 1-8 (2017) | |
dcterms.creator | Morales Espinosa, Maria del Rosario::cvu::56786 | |
dcterms.creator | Delgado Sapien, Gabriela::cvu::664432 | |
dcterms.creator | Espinosa Camacho, Luis Fernando::cvu::619928 | |
dcterms.creator | Isselo, Dassaev::ca::1239280 | |
dcterms.creator | Alanis Mendez, Jose Luis::cvu::241545 | |
dcterms.creator | Rodriguez, Cristina::ca::1239278 | |
dcterms.creator | Miranda Novales, Maria Guadalupe::cvu::18781 | |
dcterms.creator | Cravioto Quintana, Alejandro Rafael::cvu::1509 | |
dc.identifier.doi | 10.3389/fmicb.2017.00313 | |
dc.relation.ispartofjournal | https://www.ncbi.nlm.nih.gov/pmc/issues/284457/ | |
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Archivo | Descripción | Tamaño | Formato | |
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FACMED_UNAMA58.pdf | 2.79 MB | Adobe PDF | Visualizar/Abrir |
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