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dc.contributor.authorMorales Espinosa, Maria del Rosario
dc.contributor.authorDelgado Sapien, Gabriela
dc.contributor.authorEspinosa Camacho, Luis Fernando
dc.contributor.authorIsselo, Dassaev
dc.contributor.authorAlanis Mendez, Jose Luis
dc.contributor.authorRodriguez, Cristina
dc.contributor.authorMiranda Novales, Maria Guadalupe
dc.contributor.authorCravioto Quintana, Alejandro Rafael
dc.coverage.spatialCH
dc.date.accessioned2019-06-17T17:23:28Z-
dc.date.available2019-06-17T17:23:28Z-
dc.date.issued2017
dc.identifier.urihttp://ru.facmed.unam.mx/jspui/handle/FACMED_UNAM/A58-
dc.description.abstractPseudomonas aeruginosa is an opportunistic pathogen and is associated with nosocomial infections. Its ability to thrive in a broad range of environments is due to a large and diverse genome of which its accessory genome is part. The objective of this study was to characterize P. aeruginosa strains isolated from children who developed bacteremia, using pulse-field gel electrophoresis, and in terms of its genomic islands, virulence genes, multilocus sequence type, and antimicrobial susceptibility. Our results showed that P. aeruginosa strains presented the seven virulence genes: toxA, lasB, lecA, algR, plcH, phzA1, and toxR, a type IV pilin alleles (TFP) group I or II. Additionally, we detected a novel pilin and accessory gene, expanding the number of TFP alleles to group VI. All strains presented the PAPI-2 Island and the majority were exoU+ and exoS+ genotype. Ten percent of the strains were multi-drug resistance phenotype, 18% extensively drug-resistance, 68% moderately resistance and only 3% were susceptible to all the antimicrobial tested. The most prevalent acquired ?-Lactamase was KPC. We identified a group of ST309 strains, as a potential high risk clone. Our finding also showed that the strains isolated from patients with bacteremia have important virulence factors involved in colonization and dissemination as: a TFP group I or II; the presence of the exoU gene within the PAPI-2 island and the presence of the exoS gene.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.rightsopenAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.subjectBacteriología
dc.subjectPseudomona aeruginosa
dc.subjectGenes exoS y exoU
dc.subjectGenómica
dc.subjectAlelos de TFP
dc.subjectST309
dc.subjectBacteremia
dc.subject.classificationMedicina y Ciencias de la Salud
dc.subject.otherBacteriology
dc.subject.otherPseudomonas aeruginosa
dc.subject.otherexoS and exoU genes
dc.subject.otherGenomics
dc.subject.otherTFP alleles
dc.subject.otherST309
dc.subject.otherBacteremia
dc.titleFingerprint Analysis and Identification of Strains ST309 as a Potential High Risk Clone in a Pseudomonas aeruginosa Population Isolated from Children with Bacteremia in Mexico City.
dc.typeArtículo
dc.typepublishedVersion
dcterms.bibliographicCitationFrontiers in Microbiology (1664-302X) vol. 8, 1-8 (2017)
dcterms.creatorMorales Espinosa, Maria del Rosario::cvu::56786
dcterms.creatorDelgado Sapien, Gabriela::cvu::664432
dcterms.creatorEspinosa Camacho, Luis Fernando::cvu::619928
dcterms.creatorIsselo, Dassaev::ca::1239280
dcterms.creatorAlanis Mendez, Jose Luis::cvu::241545
dcterms.creatorRodriguez, Cristina::ca::1239278
dcterms.creatorMiranda Novales, Maria Guadalupe::cvu::18781
dcterms.creatorCravioto Quintana, Alejandro Rafael::cvu::1509
dc.identifier.doi10.3389/fmicb.2017.00313
dc.relation.ispartofjournalhttps://www.ncbi.nlm.nih.gov/pmc/issues/284457/
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