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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Rangel, Adrián | |
dc.contributor.author | Lawrence Bernstein | |
dc.contributor.author | Mandujano Tinoco, Edna Ayerim | |
dc.contributor.author | García, Silvia Julieta | |
dc.contributor.author | Garcia Contreras, Rodolfo | |
dc.coverage.spatial | CH | |
dc.date.accessioned | 2019-06-17T17:23:42Z | - |
dc.date.available | 2019-06-17T17:23:42Z | - |
dc.date.issued | 2015 | |
dc.identifier.uri | http://ru.facmed.unam.mx/jspui/handle/FACMED_UNAM/A8 | - |
dc.description.abstract | Bacterial infection remains one of the leading causes of death worldwide, and the options for treating such infections are decreasing, due the rise of antibiotic-resistance bacteria. The pharmaceutical industry has produced few new types of antibiotics in more than a decade. Researchers are taking several approaches toward developing new classes of antibiotics, including (1) focusing on new targets and processes, such as bacterial cell-cell communication that upregulates virulence; (2) designing inhibitors of bacterial resistance, such as blockers of multidrug e?ux pumps; and (3) using alternative antimicrobials such as bacteriophages. In addition, the strategy of finding new uses for existing drugs is beginning to produce results: antibacterial properties have been discovered for existing anticancer, antifungal, anthelmintic, and anti-inflammatory drugs. In this review, we discuss the antimicrobial properties of gallium compounds, 5-fluorouracil, ciclopirox, diflunisal, and some other FDA-approved drugs and argue that their repurposing for the treatment of bacterial infections, including those that are multidrug resistance, is a feasible strategy. | |
dc.language.iso | en | |
dc.publisher | Frontiers Media SA | |
dc.rights | openAccess | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.subject | Bacteriología | |
dc.subject | Galio | |
dc.subject | 5-fluorouracilo | |
dc.subject | Infecciones bacterianas | |
dc.subject | Reutilización de fármacos | |
dc.subject.classification | Biología y Química | |
dc.subject.other | Bacteriology | |
dc.subject.other | Gallium | |
dc.subject.other | 5-fluorouracil | |
dc.subject.other | Bacterial infections | |
dc.subject.other | Drug repurposing | |
dc.title | Drug repurposing as an alternative for the treatment of recalcitrant bacterial infections. | |
dc.type | Artículo | |
dc.type | publishedVersion | |
dcterms.bibliographicCitation | Frontiers in Microbiology (1664-302X) vol. 6, 282 (2015) | |
dcterms.creator | Rangel, Adrián::ca::1239253 | |
dcterms.creator | Lawrence Bernstein::orcid::0000-0003-1783-5410 | |
dcterms.creator | Mandujano Tinoco, Edna Ayerim::cvu::441393 | |
dcterms.creator | García, Silvia Julieta::ca::1239383 | |
dcterms.creator | Garcia Contreras, Rodolfo::cvu::40169 | |
dc.identifier.doi | 10.3389/fmicb.2015.00282 | |
dc.relation.ispartofjournal | https://www.ncbi.nlm.nih.gov/pmc/issues/247997/ | |
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