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http://ru.facmed.unam.mx/jspui/handle/FACMED_UNAM/A68
Título : | The genomes of four tapeworm species reveal adaptations to parasitism. |
Autor(es) : | Isheng Jason Tsai Magdalena Zarowiecki Holroyd, Nancy Garciarrubio Granados, Alejandro Angel Sánchez Flores, Fidel Alejandro Karen Brooks Tracey, Alan Bobes Ruiz, Raul Jose Fragoso Gonzalez, Gladis del Carmen Sciutto Conde, Edda Lydia Aslett, Martin Beasley, Helen Hayley Bennett JIanping Cai Federico Camicia Clark, Richard Cucher, Marcela Nishadi De Silva Tim Day Peter Deplazes Estrada Guerra, Karel Johan Fernández, Cecilia Peter Holland Hou, Junling Songnian Hu Thomas Huckvale Hung, Stacy Kamenetzky, Laura Jacqueline A. Keane Kiss, Ferenc Uriel Koziol Lambert, Olivia Liu, Kan Xuenong Luo Yingfeng, Luo Macchiaroli, Natalia Nichol, Sarah Jordi Paps Parkinson, John Pouchkina-Stantcheva, Natasha Nick Riddiford Rosenzvit, Mara Salinas, Gustavo James Wasmuth Zamanian, Mostafa Zheng, Yadong Cai, Xuepeng Soberon, Xavier Olson, Peter Laclette Sn Roman, Juan Pedro Klaus Brehm Matthew Berriman Consorcio de laboratorios del proyecto de genoma de Taenia solium |
En : | Nature (0028-0836) vol. 496(7443), 57-63 (2013) |
Número completo : | https://www.nature.com/nature/volumes/496/issues/7443 |
Abstract : | Tapeworms (Cestoda) cause neglected diseases that can be fatal and are difficult to treat, owing to inefficient drugs. Here we present an analysis of tapeworm genome sequences using the human-infective species Echinococcus multilocularis, E. granulosus, Taenia solium and the laboratory model Hymenolepis microstoma as examples. The 115- to 141-megabase genomes offer insights into the evolution of parasitism. Synteny is maintained with distantly related blood flukes but we find extreme losses of genes and pathways that are ubiquitous in other animals, including 34 homeobox families and several determinants of stem cell fate. Tapeworms have specialized detoxification pathways, metabolism that is finely tuned to rely on nutrients scavenged from their hosts, and species-specific expansions of non-canonical heat shock proteins and families of known antigens. We identify new potential drug targets, including some on which existing pharmaceuticals may act. The genomes provide a rich resource to underpin the development of urgently needed treatments and control. |
Palabras clave : | Parasitología Taenia Secuencia genómica Tratamiento |
Fecha de publicación : | 2013 |
DOI : | 10.1038/nature12031 |
URI : | http://ru.facmed.unam.mx/jspui/handle/FACMED_UNAM/A68 |
Aparece en las colecciones: | Artículos |
Texto completo:
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FACMED_UNAMA68.pdf | 1.29 MB | Adobe PDF | Visualizar/Abrir |
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