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Título : | Drug repurposing as an alternative for the treatment of recalcitrant bacterial infections. |
Autor(es) : | Rangel, Adrián Lawrence Bernstein Mandujano Tinoco, Edna Ayerim García, Silvia Julieta Garcia Contreras, Rodolfo |
En : | Frontiers in Microbiology (1664-302X) vol. 6, 282 (2015) |
Número completo : | https://www.ncbi.nlm.nih.gov/pmc/issues/247997/ |
Abstract : | Bacterial infection remains one of the leading causes of death worldwide, and the options for treating such infections are decreasing, due the rise of antibiotic-resistance bacteria. The pharmaceutical industry has produced few new types of antibiotics in more than a decade. Researchers are taking several approaches toward developing new classes of antibiotics, including (1) focusing on new targets and processes, such as bacterial cell-cell communication that upregulates virulence; (2) designing inhibitors of bacterial resistance, such as blockers of multidrug e?ux pumps; and (3) using alternative antimicrobials such as bacteriophages. In addition, the strategy of finding new uses for existing drugs is beginning to produce results: antibacterial properties have been discovered for existing anticancer, antifungal, anthelmintic, and anti-inflammatory drugs. In this review, we discuss the antimicrobial properties of gallium compounds, 5-fluorouracil, ciclopirox, diflunisal, and some other FDA-approved drugs and argue that their repurposing for the treatment of bacterial infections, including those that are multidrug resistance, is a feasible strategy. |
Palabras clave : | Bacteriología Galio 5-fluorouracilo Infecciones bacterianas Reutilización de fármacos |
Fecha de publicación : | 2015 |
DOI : | 10.3389/fmicb.2015.00282 |
URI : | http://ru.facmed.unam.mx/jspui/handle/FACMED_UNAM/A8 |
Aparece en las colecciones: | Artículos |
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