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Título : | Prior subclinical histoplasmosis revealed in Nigeria using histoplasmin skin testing. |
Autor(es) : | Oladele, Rita Toriello Najera, Concepcion Ogunsola, Folasade Olusola Ayanlowo Foden, Philip Fayemiwo, Samuel Osaigbovo, Iriagbonse Anthony Iwuafor Shettima, Shuwaram Ekundayo, Halimat Malcolm Richardson |
En : | PLOS ONE (1932-6203) vol. 13(5) 1-11 (2018) |
Número completo : | https://www.ncbi.nlm.nih.gov/pmc/issues/311830/ |
Abstract : | OBJECTIVES: Disseminated histoplasmosis is an AIDS-defining illness. Histoplasmosis is commonly misdiagnosed as tuberculosis. Nigeria has the second highest number of people living with HIV/AIDS in Africa. The present study was carried out to investigate the prevalence of skin sensitivity amongst Nigerians to histoplasmin. DESIGN: A cross-sectional study was conducted in six centres across five geopolitical zones of Nigeria. METHODS: We recruited both healthy non-HIV and HIV-positive adults with CD4 count ? 350 cells/mm3 regardless of their ART status from March to May 2017. Skin tests were performed intradermally; induration ?5 mm were considered to be histoplasmin positive. RESULTS: 750 participants were recruited from Lagos (n = 52), Yola (n = 156), Ilorin (n = 125), Calabar (n = 120), Ibadan (n = 202) and Benin (n = 95). 467 (62.3%) were HIV negative, 247 (32.9%) were HIV positive and 36 (4.8%) did not know their HIV status. A total of 32/735 (4.4%) participants had a positive skin test. Study centre (p<0.001), education (p = 0.002) and age (p = 0.005) appeared to be significantly associated with positive skin reactivity at the 0.5% significance level, while sex (p = 0.031) and occupation (p = 0.031) would have been significant at the 5% significance level. Males had a higher rate of reactivity than females (p = 0.031, 7% vs 3%). The highest positive rates were recorded from Benin City (13/86 (15%)) and Calabar (7/120 (6%)) and no positives were recorded in Lagos (p<0.001). HIV status was not statistically significant (p = 0.70). CONCLUSION: Histoplasmosis diagnostics should be included in the Nigerian HIV guidelines. Epidemiological vigilance of progressive disseminated histoplasmosis should be considered by local health authorities. |
Palabras clave : | Micología Histoplasma capsulatum Histoplasmosis VIH Pruebas cutáneas Epidemiología de VIH |
Fecha de publicación : | 2018 |
DOI : | 10.1371/journal.pone.0196224 |
URI : | http://ru.facmed.unam.mx/jspui/handle/FACMED_UNAM/A46 |
Aparece en las colecciones: | Artículos |
Texto completo:
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FACMED_UNAMA46.pdf | 1.6 MB | Adobe PDF | Visualizar/Abrir |
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