Use el DOI o este identificador para enlazar este recurso:
http://ru.facmed.unam.mx/jspui/handle/FACMED_UNAM/A94
Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Diaz Chiguer, Dylan Lucia | |
dc.contributor.author | Hernandez Luis, Francisco | |
dc.contributor.author | Nogueda Torres, Benjamin | |
dc.contributor.author | Castillo Bocanegra, Rafael | |
dc.contributor.author | Reynoso Ducoing, Olivia Alicia | |
dc.contributor.author | Hernandez Campos, Maria Alicia | |
dc.contributor.author | Ambrosio Hernandez, Javier Rolando | |
dc.coverage.spatial | BR | |
dc.date.accessioned | 2019-06-17T17:23:54Z | - |
dc.date.available | 2019-06-17T17:23:54Z | - |
dc.date.issued | 2014 | |
dc.identifier.uri | http://ru.facmed.unam.mx/jspui/handle/FACMED_UNAM/A94 | - |
dc.description.abstract | Trypanosoma cruzi has a particular cytoskeleton that consists of a subpellicular network of microtubules and actin microfilaments. Therefore, it is an excellent target for the development of new anti-parasitic drugs. Benzimidazole 2-carbamates, a class of well-known broad-spectrum anthelmintics, have been shown to inhibit the in vitro growth of many protozoa. Therefore, to find efficient anti-trypanosomal (trypanocidal) drugs, our group has designed and synthesised several benzimidazole derivatives. One, named JVG9 (5-chloro-1H-benzimidazole-2-thiol), has been found to be effective against T. cruzi bloodstream trypomastigotes under both in vitro and in vivo conditions. Here, we present the in vitro effects observed by laser scanning confocal and scanning electron microscopy on T. cruzi trypomastigotes. Changes in the surface and the distribution of the cytoskeletal proteins are consistent with the hypothesis that the trypanocidal activity of JVG9 involves the cytoskeleton as a target. | |
dc.language.iso | en | |
dc.publisher | Fundacao Oswaldo Cruz | |
dc.rights | openAccess | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.subject | Parasitología | |
dc.subject | Trypanosoma cruzi | |
dc.subject | Benzimidazol | |
dc.subject | Citoesqueleto | |
dc.subject | Tubulina | |
dc.subject | Actina | |
dc.subject.classification | Biología y Química | |
dc.subject.other | Parasitology | |
dc.subject.other | Trypanosoma cruzi | |
dc.subject.other | Benzimidazole | |
dc.subject.other | Cytoskeleton | |
dc.subject.other | Tubulin | |
dc.subject.other | Actin | |
dc.title | JVG9, A benzimidazole derivative, Alters the surface and cytoskeleton of Trypanosoma cruzi bloodstream trypomastigotes. | |
dc.type | Artículo | |
dc.type | publishedVersion | |
dcterms.bibliographicCitation | Memórias do Instituto Oswaldo Cruz (0074-0276) vol. 109(6),757-760 (2014) | |
dcterms.creator | Diaz Chiguer, Dylan Lucia::cvu::218618 | |
dcterms.creator | Hernandez Luis, Francisco::cvu::14831 | |
dcterms.creator | Nogueda Torres, Benjamin::cvu::11761 | |
dcterms.creator | Castillo Bocanegra, Rafael::cvu::2805 | |
dcterms.creator | Reynoso Ducoing, Olivia Alicia::cvu::56287 | |
dcterms.creator | Hernandez Campos, Maria Alicia::cvu::14829 | |
dcterms.creator | Ambrosio Hernandez, Javier Rolando::cvu::120362 | |
dc.identifier.doi | 10.1590/0074-0276140096 | |
dc.relation.ispartofjournal | https://memorias.ioc.fiocruz.br/content/past-issues/past/121 | |
Aparece en las colecciones: | Artículos |
Texto completo:
Archivo | Descripción | Tamaño | Formato | |
---|---|---|---|---|
FACMED_UNAMA94.pdf | 490.34 kB | Adobe PDF | Visualizar/Abrir |
Este recurso está sujeto a una Licencia Creative Commons