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http://ru.facmed.unam.mx/jspui/handle/FACMED_UNAM/A66
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Castañeda Tamez, Paulina | |
dc.contributor.author | Ramírez, Jimena | |
dc.contributor.author | Perez Velazquez, Judith | |
dc.contributor.author | Kuttler, Christina | |
dc.contributor.author | Jalalimanesh, Ammar | |
dc.contributor.author | Saucedo, Miguel | |
dc.contributor.author | Jimenez Cortes, Jesus Guillermo | |
dc.contributor.author | Maeda, Toshinari | |
dc.contributor.author | Gonzalez Tinoco, Yael | |
dc.contributor.author | Tomás, María | |
dc.contributor.author | Wood, Thomas | |
dc.contributor.author | Garcia Contreras, Rodolfo | |
dc.coverage.spatial | CH | |
dc.date.accessioned | 2019-06-17T17:23:32Z | - |
dc.date.available | 2019-06-17T17:23:32Z | - |
dc.date.issued | 2018 | |
dc.identifier.uri | http://ru.facmed.unam.mx/jspui/handle/FACMED_UNAM/A66 | - |
dc.description.abstract | Quorum sensing (QS) in Pseudomonas aeruginosa coordinates the expression of virulence factors, such as exoproteases and siderophores, that are public goods utilized by the whole population of bacteria, regardless of whether they invested or not in their production. These public goods can be used by QS defective mutants for growth and since these mutants do not contribute to public goods production, they are considered social cheaters. Pyocyanin is a phenazine that is a toxic, QS-controlled metabolite produced by P. aeruginosa. It is a redox-active compound and promotes the generation of reactive oxygen species; it also possesses antibacterial properties and increases fitness in competition with other bacterial species. Since QS-deficient individuals are less able to tolerate oxidative stress, we hypothesized that the pyocyanin produced by the wild-type population could promote selection of functional QS systems in this bacterium. Here, we demonstrate, using competition experiments and mathematical models, that indeed pyocyanin increases the fitness of the cooperative QS-proficient individuals and restricts the appearance and selection of social cheaters. In addition, we also show that pyocyanin is able to select QS in other bacteria such as Acinetobacter baumannii. | |
dc.language.iso | en | |
dc.publisher | Frontiers Media S.A. | |
dc.rights | openAccess | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.subject | Bacteriología | |
dc.subject | Piocianina | |
dc.subject | Comunicación de quorum | |
dc.subject | Estrés oxidativo | |
dc.subject | Pseudomonas aeruginosa | |
dc.subject.classification | Biología y Química | |
dc.subject.other | Bacteriology | |
dc.subject.other | Pyocyanin|Quorum sensing | |
dc.subject.other | Oxidative stress | |
dc.subject.other | Policing | |
dc.subject.other | Pseudomona aeruginosa | |
dc.title | Pyocyanin restricts social cheating in Pseudomonas aeruginosa. | |
dc.type | Artículo | |
dc.type | publishedVersion | |
dcterms.bibliographicCitation | Frontiers in Microbiology (1664-302X) vol. 9, 1-10 (2018) | |
dcterms.creator | Castañeda Tamez, Paulina::cvu::708685 | |
dcterms.creator | Ramírez, Jimena::ca::1239316 | |
dcterms.creator | Perez Velazquez, Judith::cvu::39273 | |
dcterms.creator | Kuttler, Christina::ca::1239276 | |
dcterms.creator | Jalalimanesh, Ammar::ca::1239261 | |
dcterms.creator | Saucedo, Miguel::ca::1239351 | |
dcterms.creator | Jimenez Cortes, Jesus Guillermo::cvu::204973 | |
dcterms.creator | Maeda, Toshinari::ca::815544 | |
dcterms.creator | Gonzalez Tinoco, Yael::cvu::205598 | |
dcterms.creator | Tomás, María::ca::1239346 | |
dcterms.creator | Wood, Thomas::ca::817165 | |
dcterms.creator | Garcia Contreras, Rodolfo::cvu::40169 | |
dc.identifier.doi | https://doi.org/10.3389/fmicb.2018.01348 | |
dc.relation.ispartofjournal | https://www.ncbi.nlm.nih.gov/pmc/issues/305169/ | |
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