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http://ru.facmed.unam.mx/jspui/handle/FACMED_UNAM/A46
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Oladele, Rita | |
dc.contributor.author | Toriello Najera, Concepcion | |
dc.contributor.author | Ogunsola, Folasade | |
dc.contributor.author | Olusola Ayanlowo | |
dc.contributor.author | Foden, Philip | |
dc.contributor.author | Fayemiwo, Samuel | |
dc.contributor.author | Osaigbovo, Iriagbonse | |
dc.contributor.author | Anthony Iwuafor | |
dc.contributor.author | Shettima, Shuwaram | |
dc.contributor.author | Ekundayo, Halimat | |
dc.contributor.author | Malcolm Richardson | |
dc.coverage.spatial | US | |
dc.date.accessioned | 2019-06-17T17:23:21Z | - |
dc.date.available | 2019-06-17T17:23:21Z | - |
dc.date.issued | 2018 | |
dc.identifier.uri | http://ru.facmed.unam.mx/jspui/handle/FACMED_UNAM/A46 | - |
dc.description.abstract | OBJECTIVES: Disseminated histoplasmosis is an AIDS-defining illness. Histoplasmosis is commonly misdiagnosed as tuberculosis. Nigeria has the second highest number of people living with HIV/AIDS in Africa. The present study was carried out to investigate the prevalence of skin sensitivity amongst Nigerians to histoplasmin. DESIGN: A cross-sectional study was conducted in six centres across five geopolitical zones of Nigeria. METHODS: We recruited both healthy non-HIV and HIV-positive adults with CD4 count ? 350 cells/mm3 regardless of their ART status from March to May 2017. Skin tests were performed intradermally; induration ?5 mm were considered to be histoplasmin positive. RESULTS: 750 participants were recruited from Lagos (n = 52), Yola (n = 156), Ilorin (n = 125), Calabar (n = 120), Ibadan (n = 202) and Benin (n = 95). 467 (62.3%) were HIV negative, 247 (32.9%) were HIV positive and 36 (4.8%) did not know their HIV status. A total of 32/735 (4.4%) participants had a positive skin test. Study centre (p<0.001), education (p = 0.002) and age (p = 0.005) appeared to be significantly associated with positive skin reactivity at the 0.5% significance level, while sex (p = 0.031) and occupation (p = 0.031) would have been significant at the 5% significance level. Males had a higher rate of reactivity than females (p = 0.031, 7% vs 3%). The highest positive rates were recorded from Benin City (13/86 (15%)) and Calabar (7/120 (6%)) and no positives were recorded in Lagos (p<0.001). HIV status was not statistically significant (p = 0.70). CONCLUSION: Histoplasmosis diagnostics should be included in the Nigerian HIV guidelines. Epidemiological vigilance of progressive disseminated histoplasmosis should be considered by local health authorities. | |
dc.language.iso | en | |
dc.publisher | Public Library of Science | |
dc.rights | openAccess | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.subject | Micología | |
dc.subject | Histoplasma capsulatum | |
dc.subject | Histoplasmosis | |
dc.subject | VIH | |
dc.subject | Pruebas cutáneas | |
dc.subject | Epidemiología de VIH | |
dc.subject.classification | Medicina y Ciencias de la Salud | |
dc.subject.other | Micology | |
dc.subject.other | Histoplasma capsulatum | |
dc.subject.other | Histoplasmosis | |
dc.subject.other | HIV | |
dc.subject.other | Skin tests | |
dc.subject.other | HIV epidemiology | |
dc.title | Prior subclinical histoplasmosis revealed in Nigeria using histoplasmin skin testing. | |
dc.type | Artículo | |
dc.type | publishedVersion | |
dcterms.bibliographicCitation | PLOS ONE (1932-6203) vol. 13(5) 1-11 (2018) | |
dcterms.creator | Oladele, Rita::ca::1239372 | |
dcterms.creator | Toriello Najera, Concepcion::cvu::1669 | |
dcterms.creator | Ogunsola, Folasade::ca::1239298 | |
dcterms.creator | Olusola Ayanlowo::orcid::0000-0002-1134-3813 | |
dcterms.creator | Foden, Philip::ca::1239367 | |
dcterms.creator | Fayemiwo, Samuel::orcid::0000-0001-8937-3353 | |
dcterms.creator | Osaigbovo, Iriagbonse::ca::1239309 | |
dcterms.creator | Anthony Iwuafor::orcid::0000-0001-6796-3870 | |
dcterms.creator | Shettima, Shuwaram::ca::1239382 | |
dcterms.creator | Ekundayo, Halimat::ca::1239305 | |
dcterms.creator | Malcolm Richardson::orcid::0000-0001-5672-9552 | |
dc.identifier.doi | 10.1371/journal.pone.0196224 | |
dc.relation.ispartofjournal | https://www.ncbi.nlm.nih.gov/pmc/issues/311830/ | |
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