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http://ru.facmed.unam.mx/jspui/handle/FACMED_UNAM/A107
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Chaires Rosas, Casandra Paulina | |
dc.contributor.author | Ambriz Peña, Xochitl | |
dc.contributor.author | Montesinos Montesinos, Juan Jose | |
dc.contributor.author | Hernandez Tellez, Beatriz | |
dc.contributor.author | Piñon Zarate, Gabriela | |
dc.contributor.author | Herrera Enriquez, Miguel Angel | |
dc.contributor.author | Hernandez Estevez, Erika Ayde | |
dc.contributor.author | Ambrosio Hernandez, Javier Rolando | |
dc.contributor.author | Castell Rodriguez, Andres Eliu | |
dc.coverage.spatial | GB | |
dc.date.accessioned | 2019-06-17T17:23:07Z | - |
dc.date.available | 2019-06-17T17:23:07Z | - |
dc.date.issued | 2019 | |
dc.identifier.uri | http://ru.facmed.unam.mx/jspui/handle/FACMED_UNAM/A107 | - |
dc.description.abstract | Mesenchymal stem cells isolated from different tissues should share associated markers and the capability to differentiate to mesodermal lineages. However, their behavior varies in specific microenvironments. Herein, adhesion and fibrinolytic activity of mesenchymal stem cells from placenta, bone marrow, and Wharton’s jelly were evaluated in fibrin hydrogels prepared with nonpurified blood plasma and compared with two-dimensional cultures. Despite the source, mesenchymal stem cells adhered through focal adhesions positive for vinculin and integrin ?V in two dimensions, while focal adhesions could not be detected in fibrin hydrogels. Moreover, some cells could not spread and stay rounded. The proportions of elongated and round phenotypes varied, with placenta mesenchymal stem cells having the lowest percentage of elongated cells (~10%). Mesenchymal stem cells degraded fibrin at distinct rates, and placenta mesenchymal stem cells had the strongest fibrinolytic activity, which was achieved principally through the plasminogen–plasmin axis. These findings might have clinical implications in tissue engineering and wound healing therapy. | |
dc.language.iso | en | |
dc.publisher | SAGE-Hindawi Access to Research | |
dc.rights | openAccess | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.subject | Células troncales mesenquimales humanas | |
dc.subject | Fibrina | |
dc.subject | Adhesión | |
dc.subject | Fibrinólisis | |
dc.subject.classification | Biología y Química | |
dc.subject.other | Human mesenchymal stem cells | |
dc.subject.other | Fibrin | |
dc.subject.other | Adhesion | |
dc.subject.other | Fibrinolysis | |
dc.title | Differential adhesion and fibrinolytic activity of mesenchymal stem cells from human bone marrow, placenta, and Wharton’s jelly cultured in a fibrin hydrogel. | |
dc.type | Artículo | |
dc.type | publishedVersion | |
dcterms.bibliographicCitation | Journal of Tissue Engineering (2041-7314) Vol. 10, 1-17 (2019) | |
dcterms.creator | Chaires Rosas, Casandra Paulina::cvu::418147 | |
dcterms.creator | Ambriz Peña, Xochitl::cvu::267835 | |
dcterms.creator | Montesinos Montesinos, Juan Jose::cvu::121752 | |
dcterms.creator | Hernandez Tellez, Beatriz::cvu::898850 | |
dcterms.creator | Piñon Zarate, Gabriela::cvu::175653 | |
dcterms.creator | Herrera Enriquez, Miguel Angel::ca::297450 | |
dcterms.creator | Hernandez Estevez, Erika Ayde::cvu::545277 | |
dcterms.creator | Ambrosio Hernandez, Javier Rolando::cvu::120362 | |
dcterms.creator | Castell Rodriguez, Andres Eliu::cvu::9608 | |
dc.identifier.doi | 10.1177/2041731419840622 | |
dc.relation.ispartofjournal | https://journals.sagepub.com/toc/teja/10 | |
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FACMED_UNAMA107.pdf | 2.21 MB | Adobe PDF | Visualizar/Abrir |
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